5MIM

Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n

5MIM の概要

• エントリーDOI: 10.2210/pdb5mim/pdb
• 分子名称: Furin, CALCIUM ION, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: proprotein convertase, inhibitor, protease, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein : P09958
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53811.61

構造登録者

Dahms, S.O.,Guan-Sheng, J.,Than, M.E. (登録日: 2016-11-28, 公開日: 2017-05-10, 最終更新日: 2024-01-17)

• 主引用文献: Dahms, S.O.,Jiao, G.S.,Than, M.E.; Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.; ACS Chem. Biol., 12:1211-1216, 2017; PubMed: 28402100; DOI: 10.1021/acschembio.6b01110

実験手法

X-RAY DIFFRACTION (1.9 Å)