5MIM

Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n

5MIM の概要

分子名称Furin, CALCIUM ION, SODIUM ION, ... (6 entities in total)
機能のキーワードproprotein convertase, inhibitor, protease, complex, hydrolase
由来する生物種Homo sapiens (Human)
細胞内の位置Golgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein  P09958
ポリマー鎖数1
分子量合計53811.61
構造登録者
Dahms, S.O.,Guan-Sheng, J.,Than, M.E. (登録日: 2016-11-28, 公開日: 2017-05-10, 最終更新日: 2017-05-31)
主引用文献
Dahms, S.O.,Jiao, G.S.,Than, M.E.
Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem. Biol., 12:1211-1216, 2017
PubMed: 28402100 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acschembio.6b01110
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.9 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.185101.6%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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