5MH6

D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-ketohexanoic acid and NAD+ (1.35 A resolution)

Summary for 5MH6

• Entry DOI: 10.2210/pdb5mh6/pdb
• Related: 5MH5
• Descriptor: D-2-hydroxyacid dehydrogenase, 1,2-ETHANEDIOL, SULFATE ION, ... (8 entities in total)
• Functional Keywords: d-2-hydroxyacid dehydrogenase, halophile, chiral specificity, reaction mechanism, oxidoreductase
• Biological source: Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)
• Total number of polymer chains: 4
• Total formula weight: 139025.28

Authors

Bisson, C.,Baker, P.J.,Domenech Perez, J.,Pramanpol, N.,Harding, S.E.,Rice, D.W.,Ferrer, J. (deposition date: 2016-11-23, release date: 2018-06-06, Last modification date: 2022-12-28)

• Primary citation: Domenech Perez, J.,Pramanpol, N.,Baker, P.J.,Bisson, C.,Harding, S.E.,Rice, D.W.,Ferrer, J.; Productive ternary complexes of D-2-hydroxyacid dehydrogenase provide insights into the chiral specificity of its reaction mechanism; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.35 Å)