5MGV

Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2

Summary for 5MGV

Entry DOI	10.2210/pdb5mgv/pdb
Descriptor	Phenylalanine--tRNA ligase, mitochondrial (2 entities in total)
Functional Keywords	crystal structure of pathogenic human mitochondrial phers, molecular dynamic, kinetik study, aminoacylation, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	47519.94
Authors	Kartvelishvili, E.,Tworowski, D.,Vernon, H.,Chrzanowska-Lightowlers, Z.,Moor, N.,Wang, J.,Wong, L.-J.,Safro, M. (deposition date: 2016-11-22, release date: 2017-05-03, Last modification date: 2024-05-08)
Primary citation	Kartvelishvili, E.,Tworowski, D.,Vernon, H.,Moor, N.,Wang, J.,Wong, L.J.,Chrzanowska-Lightowlers, Z.,Safro, M. Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26:1505-1516, 2017 Cited by PubMed: 28419689 DOI: 10.1002/pro.3176 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation