5MAR

Structure of human SIRT2 in complex with 1,2,4-Oxadiazole inhibitor and ADP ribose.

5MAR の概要

• エントリーDOI: 10.2210/pdb5mar/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (9 entities in total)
• 機能のキーワード: sirtuin, nad-dependent protein deacylase, inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71700.89

構造登録者

Moniot, S.,Steegborn, C. (登録日: 2016-11-04, 公開日: 2017-03-15, 最終更新日: 2024-01-17)

• 主引用文献: Moniot, S.,Forgione, M.,Lucidi, A.,Hailu, G.S.,Nebbioso, A.,Carafa, V.,Baratta, F.,Altucci, L.,Giacche, N.,Passeri, D.,Pellicciari, R.,Mai, A.,Steegborn, C.,Rotili, D.; Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.; J. Med. Chem., 60:2344-2360, 2017; PubMed: 28240897; DOI: 10.1021/acs.jmedchem.6b01609

実験手法

X-RAY DIFFRACTION (1.89 Å)