5M6X

Crystal Structure of human RhoGAP mutated in its arginine finger (R85A) in complex with RhoA.GDP.MgF3- human

Summary for 5M6X

Entry DOI	10.2210/pdb5m6x/pdb
Related	5C4M
Descriptor	Rho GTPase-activating protein 1, Transforming protein RhoA, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	rhogap, arginine finger, rhoa, transition state, signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q07960 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains	4
Total formula weight	98743.69
Authors	Pellegrini, E.,Bowler, M.W. (deposition date: 2016-10-26, release date: 2017-05-17, Last modification date: 2024-01-17)
Primary citation	Jin, Y.,Molt, R.W.,Pellegrini, E.,Cliff, M.J.,Bowler, M.W.,Richards, N.G.J.,Blackburn, G.M.,Waltho, J.P. Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches. Angew. Chem. Int. Ed. Engl., 56:9732-9735, 2017 Cited by PubMed: 28498638 DOI: 10.1002/anie.201703074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation