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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5M6X

Crystal Structure of human RhoGAP mutated in its arginine finger (R85A) in complex with RhoA.GDP.MgF3- human

Functional Information from GO Data
ChainGOidnamespacecontents
A0007165biological_processsignal transduction
B0000166molecular_functionnucleotide binding
B0000281biological_processmitotic cytokinesis
B0002363biological_processalpha-beta T cell lineage commitment
B0003189biological_processaortic valve formation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0007264biological_processsmall GTPase-mediated signal transduction
B0007266biological_processRho protein signal transduction
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010812biological_processnegative regulation of cell-substrate adhesion
B0016477biological_processcell migration
B0016787molecular_functionhydrolase activity
B0017022molecular_functionmyosin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030027cellular_componentlamellipodium
B0030036biological_processactin cytoskeleton organization
B0030054cellular_componentcell junction
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030667cellular_componentsecretory granule membrane
B0031122biological_processcytoplasmic microtubule organization
B0031982cellular_componentvesicle
B0032154cellular_componentcleavage furrow
B0032467biological_processpositive regulation of cytokinesis
B0032587cellular_componentruffle membrane
B0032956biological_processregulation of actin cytoskeleton organization
B0033688biological_processregulation of osteoblast proliferation
B0034329biological_processcell junction assembly
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035385biological_processRoundabout signaling pathway
B0036089biological_processcleavage furrow formation
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0042476biological_processodontogenesis
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043149biological_processstress fiber assembly
B0043197cellular_componentdendritic spine
B0043296cellular_componentapical junction complex
B0043297biological_processapical junction assembly
B0043366biological_processbeta selection
B0043542biological_processendothelial cell migration
B0043931biological_processossification involved in bone maturation
B0044319biological_processwound healing, spreading of cells
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045666biological_processpositive regulation of neuron differentiation
B0045792biological_processnegative regulation of cell size
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0050919biological_processnegative chemotaxis
B0051301biological_processcell division
B0051496biological_processpositive regulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060193biological_processpositive regulation of lipase activity
B0061430biological_processbone trabecula morphogenesis
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0071222biological_processcellular response to lipopolysaccharide
B0071345biological_processcellular response to cytokine stimulus
B0071526biological_processsemaphorin-plexin signaling pathway
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
B0090307biological_processmitotic spindle assembly
B0090324biological_processnegative regulation of oxidative phosphorylation
B0097498biological_processendothelial tube lumen extension
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0101003cellular_componentficolin-1-rich granule membrane
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1902766biological_processskeletal muscle satellite cell migration
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903673biological_processmitotic cleavage furrow formation
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
B1990869biological_processcellular response to chemokine
B2000406biological_processpositive regulation of T cell migration
H0007165biological_processsignal transduction
I0000166molecular_functionnucleotide binding
I0000281biological_processmitotic cytokinesis
I0002363biological_processalpha-beta T cell lineage commitment
I0003189biological_processaortic valve formation
I0003924molecular_functionGTPase activity
I0003925molecular_functionG protein activity
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005768cellular_componentendosome
I0005789cellular_componentendoplasmic reticulum membrane
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0005925cellular_componentfocal adhesion
I0005938cellular_componentcell cortex
I0007264biological_processsmall GTPase-mediated signal transduction
I0007266biological_processRho protein signal transduction
I0009898cellular_componentcytoplasmic side of plasma membrane
I0010812biological_processnegative regulation of cell-substrate adhesion
I0016477biological_processcell migration
I0016787molecular_functionhydrolase activity
I0017022molecular_functionmyosin binding
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030027cellular_componentlamellipodium
I0030036biological_processactin cytoskeleton organization
I0030054cellular_componentcell junction
I0030334biological_processregulation of cell migration
I0030335biological_processpositive regulation of cell migration
I0030425cellular_componentdendrite
I0030496cellular_componentmidbody
I0030667cellular_componentsecretory granule membrane
I0031122biological_processcytoplasmic microtubule organization
I0031982cellular_componentvesicle
I0032154cellular_componentcleavage furrow
I0032467biological_processpositive regulation of cytokinesis
I0032587cellular_componentruffle membrane
I0032956biological_processregulation of actin cytoskeleton organization
I0033688biological_processregulation of osteoblast proliferation
I0034329biological_processcell junction assembly
I0034446biological_processsubstrate adhesion-dependent cell spreading
I0035385biological_processRoundabout signaling pathway
I0036089biological_processcleavage furrow formation
I0038027biological_processapolipoprotein A-I-mediated signaling pathway
I0042476biological_processodontogenesis
I0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
I0043149biological_processstress fiber assembly
I0043197cellular_componentdendritic spine
I0043296cellular_componentapical junction complex
I0043297biological_processapical junction assembly
I0043366biological_processbeta selection
I0043542biological_processendothelial cell migration
I0043931biological_processossification involved in bone maturation
I0044319biological_processwound healing, spreading of cells
I0045198biological_processestablishment of epithelial cell apical/basal polarity
I0045666biological_processpositive regulation of neuron differentiation
I0045792biological_processnegative regulation of cell size
I0046638biological_processpositive regulation of alpha-beta T cell differentiation
I0050919biological_processnegative chemotaxis
I0051301biological_processcell division
I0051496biological_processpositive regulation of stress fiber assembly
I0051893biological_processregulation of focal adhesion assembly
I0060071biological_processWnt signaling pathway, planar cell polarity pathway
I0060193biological_processpositive regulation of lipase activity
I0061430biological_processbone trabecula morphogenesis
I0070062cellular_componentextracellular exosome
I0070507biological_processregulation of microtubule cytoskeleton organization
I0071222biological_processcellular response to lipopolysaccharide
I0071345biological_processcellular response to cytokine stimulus
I0071526biological_processsemaphorin-plexin signaling pathway
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0071944cellular_componentcell periphery
I0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
I0090307biological_processmitotic spindle assembly
I0090324biological_processnegative regulation of oxidative phosphorylation
I0097498biological_processendothelial tube lumen extension
I0098794cellular_componentpostsynapse
I0098978cellular_componentglutamatergic synapse
I0099159biological_processregulation of modification of postsynaptic structure
I0101003cellular_componentficolin-1-rich granule membrane
I1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
I1902766biological_processskeletal muscle satellite cell migration
I1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
I1903673biological_processmitotic cleavage furrow formation
I1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
I1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
I1990869biological_processcellular response to chemokine
I2000406biological_processpositive regulation of T cell migration
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MG B 201
ChainResidue
BTHR19
BTHR37
BGDP202
BMGF203
BHOH301
BHOH306
site_idAC2
Number of Residues22
Detailsbinding site for residue GDP B 202
ChainResidue
BCYS16
BGLY17
BLYS18
BTHR19
BCYS20
BPHE30
BTYR34
BLYS118
BASP120
BLEU121
BSER160
BALA161
BLYS162
BMG201
BMGF203
BHOH301
BHOH306
BHOH315
BHOH316
ALYS189
AHOH311
BALA15
site_idAC3
Number of Residues12
Detailsbinding site for residue MGF B 203
ChainResidue
BGLY14
BLYS18
BTYR34
BPRO36
BTHR37
BGLY62
BGLN63
BMG201
BGDP202
BHOH301
BHOH306
BHOH309
site_idAC4
Number of Residues6
Detailsbinding site for residue MG I 201
ChainResidue
ITHR19
ITHR37
IGDP202
IMGF203
IHOH306
IHOH314
site_idAC5
Number of Residues22
Detailsbinding site for residue GDP I 202
ChainResidue
HLYS189
IALA15
ICYS16
IGLY17
ILYS18
ITHR19
ICYS20
IPHE30
ITYR34
ILYS118
IASP120
ILEU121
ISER160
IALA161
ILYS162
IMG201
IMGF203
IHOH303
IHOH306
IHOH314
IHOH316
IHOH328
site_idAC6
Number of Residues13
Detailsbinding site for residue MGF I 203
ChainResidue
IGLY14
IALA15
ILYS18
ITYR34
IPRO36
ITHR37
IGLY62
IGLN63
IMG201
IGDP202
IHOH306
IHOH311
IHOH314
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSite: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues34
DetailsRegion: {"description":"Switch II region; involved in RAP1GDS1 isoform 2 binding","evidences":[{"source":"PubMed","id":"30190425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZHX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10748207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777804","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues26
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"PubMed","id":"1328215","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"Q9QUI0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23871831","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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