5M6M

Small Molecule inhibitors of IAP

Summary for 5M6M

Entry DOI	10.2210/pdb5m6m/pdb
Descriptor	E3 ubiquitin-protein ligase XIAP, ZINC ION, SODIUM ION, ... (5 entities in total)
Functional Keywords	xiap, apoptosis, metal-binding, inhibitor, xiap#1
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P98170
Total number of polymer chains	1
Total formula weight	15140.33
Authors	Williams, P.A. (deposition date: 2016-10-25, release date: 2017-05-24, Last modification date: 2017-06-21)
Primary citation	Tamanini, E.,Buck, I.M.,Chessari, G.,Chiarparin, E.,Day, J.E.H.,Frederickson, M.,Griffiths-Jones, C.M.,Hearn, K.,Heightman, T.D.,Iqbal, A.,Johnson, C.N.,Lewis, E.J.,Martins, V.,Peakman, T.,Reader, M.,Rich, S.J.,Ward, G.A.,Williams, P.A.,Wilsher, N.E. Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60:4611-4625, 2017 Cited by PubMed: 28492317 DOI: 10.1021/acs.jmedchem.6b01877 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation