5M5E
Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor
Summary for 5M5E
Entry DOI | 10.2210/pdb5m5e/pdb |
Descriptor | Interleukin-2 receptor subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... (11 entities in total) |
Functional Keywords | interleukine-2, interleukine-2 receptor, immune system, cytokine, interleukine-2 variant |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 78101.86 |
Authors | Klein, C.,Freimoser-Grundschober, A.,Waldhauer, I.,Stihle, M.,Birk, M.,Benz, J. (deposition date: 2016-10-21, release date: 2017-05-03, Last modification date: 2024-01-17) |
Primary citation | Klein, C.,Waldhauer, I.,Nicolini, V.G.,Freimoser-Grundschober, A.,Nayak, T.,Vugts, D.J.,Dunn, C.,Bolijn, M.,Benz, J.,Stihle, M.,Lang, S.,Roemmele, M.,Hofer, T.,van Puijenbroek, E.,Wittig, D.,Moser, S.,Ast, O.,Brunker, P.,Gorr, I.H.,Neumann, S.,de Vera Mudry, M.C.,Hinton, H.,Crameri, F.,Saro, J.,Evers, S.,Gerdes, C.,Bacac, M.,van Dongen, G.,Moessner, E.,Umana, P. Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Oncoimmunology, 6:e1277306-e1277306, 2017 Cited by PubMed: 28405498DOI: 10.1080/2162402X.2016.1277306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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