5M53
Nek2 bound to arylaminopurine inhibitor 11
Summary for 5M53
Entry DOI | 10.2210/pdb5m53/pdb |
Descriptor | Serine/threonine-protein kinase Nek2, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N},~{N}-dimethyl-benzamide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
Functional Keywords | protein kinase, inhibitor, centrosome separation, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Nucleus: P51955 |
Total number of polymer chains | 1 |
Total formula weight | 33991.45 |
Authors | Bayliss, R.,Carr, K.H. (deposition date: 2016-10-20, release date: 2016-11-09, Last modification date: 2024-01-17) |
Primary citation | Coxon, C.R.,Wong, C.,Bayliss, R.,Boxall, K.,Carr, K.H.,Fry, A.M.,Hardcastle, I.R.,Matheson, C.J.,Newell, D.R.,Sivaprakasam, M.,Thomas, H.,Turner, D.,Yeoh, S.,Wang, L.Z.,Griffin, R.J.,Golding, B.T.,Cano, C. Structure-guided design of purine-based probes for selective Nek2 inhibition. Oncotarget, 8:19089-19124, 2017 Cited by PubMed: 27833088DOI: 10.18632/oncotarget.13249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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