5M53
Nek2 bound to arylaminopurine inhibitor 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase Nek2 | polymer | 279 | 32632.5 | 1 | UniProt (P51955) Pfam (PF00069) | Homo sapiens (Human) | HSPK 21,Never in mitosis A-related kinase 2,NimA-related protein kinase 2,NimA-like protein kinase 1 |
| 2 | B (A) | 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N},~{N}-dimethyl-benzamide | non-polymer | 394.5 | 1 | Chemie (7GJ) | |||
| 3 | C, D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | E, F, G, H, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | K, L, M, N (A) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 6 | O (A) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 1 - 271 (UniProt: P51955)
| PDB | External Database | Details |
|---|---|---|
| Ala 175 | Thr 175 | conflict |
| Leu 272 | - | expression tag |
| Glu 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
| His 277 | - | expression tag |
| His 278 | - | expression tag |
| His 279 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32632.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1359.0 | |
| All* | Total formula weight | 33991.5 |
