5M37
The molecular tweezer CLR01 stabilizes a disordered protein-protein interface
Summary for 5M37
Entry DOI | 10.2210/pdb5m37/pdb |
Related | 5D3F 5EWZ 5EXA |
Descriptor | 14-3-3 protein zeta/delta, M-phase inducer phosphatase 3, (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, ... (5 entities in total) |
Functional Keywords | stabilization, 14-3-3, disordered ppi interface, cdc25c, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 60613.63 |
Authors | Bier, D.,Ottmann, C. (deposition date: 2016-10-14, release date: 2017-11-15, Last modification date: 2024-01-17) |
Primary citation | Bier, D.,Mittal, S.,Bravo-Rodriguez, K.,Sowislok, A.,Guillory, X.,Briels, J.,Heid, C.,Bartel, M.,Wettig, B.,Brunsveld, L.,Sanchez-Garcia, E.,Schrader, T.,Ottmann, C. The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139:16256-16263, 2017 Cited by PubMed: 29039919DOI: 10.1021/jacs.7b07939 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
Download full validation report