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5M32

Human 26S proteasome in complex with Oprozomib

Summary for 5M32
Entry DOI10.2210/pdb5m32/pdb
EMDB information4146
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (35 entities in total)
Functional Keywordsproteasome, oprozomib, ups, drug-binding, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains47
Total formula weight1535198.08
Authors
Haselbach, D.,Schrader, J.,Lambrecht, F.,Henneberg, F.,Chari, A.,Stark, H. (deposition date: 2016-10-14, release date: 2017-07-05, Last modification date: 2019-12-11)
Primary citationHaselbach, D.,Schrader, J.,Lambrecht, F.,Henneberg, F.,Chari, A.,Stark, H.
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
Nat Commun, 8:15578-15578, 2017
Cited by
PubMed: 28541292
DOI: 10.1038/ncomms15578
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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