5M2V
Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution
5M2V の概要
エントリーDOI | 10.2210/pdb5m2v/pdb |
分子名称 | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid, SULFATE ION, ... (4 entities in total) |
機能のキーワード | kainate receptor ligand-binding domain, gluk1-lbd, gluk1-s1s2, antagonist, membrane protein |
由来する生物種 | Rattus norvegicus (Norway Rat) 詳細 |
細胞内の位置 | Cell membrane; Multi-pass membrane protein: P22756 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 59366.66 |
構造登録者 | |
主引用文献 | Krogsgaard-Larsen, N.,Delgar, C.G.,Koch, K.,Brown, P.M.,Moller, C.,Han, L.,Huynh, T.H.,Hansen, S.W.,Nielsen, B.,Bowie, D.,Pickering, D.S.,Kastrup, J.S.,Frydenvang, K.,Bunch, L. Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. J. Med. Chem., 60:441-457, 2017 Cited by PubMed: 28005385DOI: 10.1021/acs.jmedchem.6b01516 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.18 Å) |
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