5LZI

Porcine heat-labile enterotoxin R13H in complex with inhibitor MM146

5LZI の概要

• エントリーDOI: 10.2210/pdb5lzi/pdb
• 分子名称: Heat-labile enterotoxin B chain, GLYCEROL, (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[(2~{R})-3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-2-(2-phenylethanoylamino)propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, ... (7 entities in total)
• 機能のキーワード: heat-labile enterotoxin, inhibitor, cholera, toxin
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 63377.72

構造登録者

Heggelund, J.E.,Mackenzie, A.,Krengel, U. (登録日: 2016-09-29, 公開日: 2017-05-31, 最終更新日: 2024-01-17)

• 主引用文献: Heggelund, J.E.,Mackenzie, A.,Martinsen, T.,Benjamin Heim, J.,Cheshev, P.,Bernardi, A.,Krengel, U.; Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.; Sci Rep, 7:2326-2326, 2017; PubMed: 28539625; DOI: 10.1038/s41598-017-02179-0

実験手法

X-RAY DIFFRACTION (1.6 Å)