5LYJ

Tubulin-Combretastatin A4 complex

Summary for 5LYJ

• Entry DOI: 10.2210/pdb5lyj/pdb
• Related: 4O2B
• Descriptor: Tubulin alpha-1B chain, Combretastatin A4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, cell cycle- inhibitor complex
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265286.93

Authors

Gaspari, R.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. (deposition date: 2016-09-28, release date: 2017-01-18, Last modification date: 2024-01-17)

• Primary citation: Gaspari, R.,Prota, A.E.,Bargsten, K.,Cavalli, A.,Steinmetz, M.O.; Structural basis of cis- and trans-combretastatin binding to tubulin; Chem, 2017; DOI: 10.1016/j.chempr.2016.12.005

Experimental method

X-RAY DIFFRACTION (2.397 Å)