5LXM
Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2
Summary for 5LXM
Entry DOI | 10.2210/pdb5lxm/pdb |
Descriptor | Aurora kinase A, MAGNESIUM ION, AMMONIA, ... (12 entities in total) |
Functional Keywords | protein kinase, proteomimetic, stapled helix peptide, mitosis, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 38589.29 |
Authors | McIntyre, P.J.,Bayliss, R. (deposition date: 2016-09-22, release date: 2016-11-02, Last modification date: 2024-02-07) |
Primary citation | Rennie, Y.K.,McIntyre, P.J.,Akindele, T.,Bayliss, R.,Jamieson, A.G. A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chem. Biol., 11:3383-3390, 2016 Cited by PubMed: 27775325DOI: 10.1021/acschembio.6b00727 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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