5LX6
Human PARP10 (ARTD10), catalytic fragment in complex with PARP inhibitor Veliparib
Summary for 5LX6
| Entry DOI | 10.2210/pdb5lx6/pdb |
| Descriptor | Poly [ADP-ribose] polymerase 10, (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium (3 entities in total) |
| Functional Keywords | transferase domain, adp-ribosylation, parp inhibitor, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus, nucleolus : Q53GL7 |
| Total number of polymer chains | 2 |
| Total formula weight | 43745.76 |
| Authors | Karlberg, T.,Thorsell, A.G.,Schuler, H. (deposition date: 2016-09-20, release date: 2017-01-11, Last modification date: 2024-01-17) |
| Primary citation | Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60:1262-1271, 2017 Cited by PubMed: 28001384DOI: 10.1021/acs.jmedchem.6b00990 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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