5LW1

Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide

5LW1 の概要

• エントリーDOI: 10.2210/pdb5lw1/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000557
• 分子名称: DD_232_11_D12, Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, ... (6 entities in total)
• 機能のキーワード: x-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions, transferase, de novo protein
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 243041.45

構造登録者

Wu, Y.,Batyuk, A.,Mittl, P.R.,Honegger, A.,Plueckthun, A. (登録日: 2016-09-15, 公開日: 2017-12-13, 最終更新日: 2024-01-17)

• 主引用文献: Wu, Y.,Honegger, A.,Batyuk, A.,Mittl, P.R.E.,Pluckthun, A.; Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.; J.Mol.Biol., 430:2128-2138, 2018; PubMed: 29126898; DOI: 10.1016/j.jmb.2017.10.032

実験手法

X-RAY DIFFRACTION (3.2 Å)