5LVP

Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket

5LVP の概要

• エントリーDOI: 10.2210/pdb5lvp/pdb
• 分子名称: 3-phosphoinositide-dependent protein kinase 1, hydrophobic-motif peptide of PKB/Akt, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: protein kinase, allosteric regulation, small compounds, pif-pocket, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 149715.93

構造登録者

Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Suess, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. (登録日: 2016-09-14, 公開日: 2016-10-19, 最終更新日: 2019-10-16)

• 主引用文献: Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Su, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M.; Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.; Cell Chem Biol, 23:1193-1205, 2016; PubMed: 27693059; DOI: 10.1016/j.chembiol.2016.06.017

実験手法

X-RAY DIFFRACTION (2.5 Å)