5LTH

Crystal structure of the alpha subunit of heme dependent oxidative N-demethylase (HODM) in complex with the dimethylamine substrate

Summary for 5LTH

Entry DOI	10.2210/pdb5lth/pdb
Descriptor	heme dependent oxidative N-demethylase, PROTOPORPHYRIN IX CONTAINING FE, DIMETHYLAMINE, ... (6 entities in total)
Functional Keywords	heme binding, pas domain, amine oxidase, dimethylamine, oxidoreductase
Biological source	Pseudomonas mendocina
Total number of polymer chains	1
Total formula weight	40952.26
Authors	Ortmayer, M.,Leys, D. (deposition date: 2016-09-06, release date: 2016-11-09, Last modification date: 2024-01-17)
Primary citation	Ortmayer, M.,Lafite, P.,Menon, B.R.,Tralau, T.,Fisher, K.,Denkhaus, L.,Scrutton, N.S.,Rigby, S.E.,Munro, A.W.,Hay, S.,Leys, D. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme. Nature, 539:593-597, 2016 Cited by PubMed: 27851736 DOI: 10.1038/nature20159 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation