5LPP

tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group C2) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

5LPP の概要

• エントリーDOI: 10.2210/pdb5lpp/pdb
• 関連するPDBエントリー: 1P0D 4KWO 4LEQ 4PUK 5I00 5I02 5I06 5LPO
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, ... (4 entities in total)
• 機能のキーワード: carbohydrate-based inhibitors, homodimer, shigellosis, transferase, transferase inhibitor
• 由来する生物種: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43421.57

構造登録者

Ehrmann, F.R.,Heine, A.,Klebe, G. (登録日: 2016-08-14, 公開日: 2017-08-30, 最終更新日: 2024-01-10)

• 主引用文献: Ehrmann, F.R.,Botzanowski, T.,Pfaffender, T.,Heine, A.,Diederich, F.,Sanglier-Cianferani, S.,Klebe, G.; Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer; To be published,

実験手法

X-RAY DIFFRACTION (1.99 Å)