5LPG
Structure of NUDT15 in complex with 6-thio-GMP
Summary for 5LPG
Entry DOI | 10.2210/pdb5lpg/pdb |
Descriptor | Probable 8-oxo-dGTP diphosphatase NUDT15, MAGNESIUM ION, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-sulfanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, ... (4 entities in total) |
Functional Keywords | mth2, dna repair enzyme, cancer, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 37770.82 |
Authors | Masuyer, G.,Carter, M.,Rehling, D.,Stenmark, P.,Helleday, T.,Jemth, A.-S.,Valerie, N.C.K.,Homan, E.,Herr, P.,Bevc, L.,Page, B.D.G.,Hagenkort, A. (deposition date: 2016-08-12, release date: 2016-08-24, Last modification date: 2024-01-10) |
Primary citation | Valerie, N.C.,Hagenkort, A.,Page, B.D.,Masuyer, G.,Rehling, D.,Carter, M.,Bevc, L.,Herr, P.,Homan, E.,Sheppard, N.G.,Stenmark, P.,Jemth, A.S.,Helleday, T. NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. Cancer Res., 76:5501-5511, 2016 Cited by PubMed: 27530327DOI: 10.1158/0008-5472.CAN-16-0584 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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