5LPG

Structure of NUDT15 in complex with 6-thio-GMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0000302	biological_process	response to reactive oxygen species
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006195	biological_process	purine nucleotide catabolic process
A	0006203	biological_process	dGTP catabolic process
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042262	biological_process	DNA protection
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	1901292	biological_process	nucleoside phosphate catabolic process
B	0000278	biological_process	mitotic cell cycle
B	0000302	biological_process	response to reactive oxygen species
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006195	biological_process	purine nucleotide catabolic process
B	0006203	biological_process	dGTP catabolic process
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042262	biological_process	DNA protection
B	0044715	molecular_function	8-oxo-dGDP phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	1901292	biological_process	nucleoside phosphate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MG A 1101

Chain	Residue
A	GLY47
A	GLU63
A	GLU67
A	HOH1210
A	HOH1211
A	HOH1228
A	HOH1263

---

site_id	AC2
Number of Residues	13
Details	binding site for residue 71V A 1102

Chain	Residue
A	PRO46
A	GLY47
A	GLY48
A	HIS49
A	TYR90
A	PHE135
A	GLY137
A	LEU138
A	HOH1211
A	HOH1218
A	HOH1227
A	ARG34
A	LEU45

---

site_id	AC3
Number of Residues	9
Details	binding site for residue MG B 1101

Chain	Residue
B	GLU63
B	GLU67
B	MG1102
B	MG1103
B	MG1104
B	HOH1209
B	HOH1215
B	HOH1230
B	HOH1267

---

site_id	AC4
Number of Residues	8
Details	binding site for residue MG B 1102

Chain	Residue
B	GLY47
B	GLU67
B	MG1101
B	MG1103
B	HOH1215
B	HOH1227
B	HOH1254
B	HOH1257

---

site_id	AC5
Number of Residues	8
Details	binding site for residue MG B 1103

Chain	Residue
B	GLY48
B	MG1101
B	MG1102
B	MG1104
B	HOH1215
B	HOH1243
B	HOH1264
B	HOH1283

---

site_id	AC6
Number of Residues	8
Details	binding site for residue MG B 1104

Chain	Residue
A	HOH1271
B	GLU63
B	MG1101
B	MG1103
B	HOH1214
B	HOH1220
B	HOH1243
B	HOH1267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU63
A	GLU67
B	GLU63
B	GLU67

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