5LPG
Structure of NUDT15 in complex with 6-thio-GMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006195 | biological_process | purine nucleotide catabolic process |
| A | 0006203 | biological_process | dGTP catabolic process |
| A | 0006950 | biological_process | response to stress |
| A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| A | 0009217 | biological_process | purine deoxyribonucleoside triphosphate catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| A | 0036217 | molecular_function | dGTP diphosphatase activity |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0042262 | biological_process | DNA protection |
| A | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| A | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| A | 0106405 | molecular_function | isoprenoid diphosphate phosphatase activity |
| A | 0120557 | molecular_function | farnesyl diphosphatase activity |
| A | 1901292 | biological_process | nucleoside phosphate catabolic process |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006195 | biological_process | purine nucleotide catabolic process |
| B | 0006203 | biological_process | dGTP catabolic process |
| B | 0006950 | biological_process | response to stress |
| B | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| B | 0009217 | biological_process | purine deoxyribonucleoside triphosphate catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| B | 0036217 | molecular_function | dGTP diphosphatase activity |
| B | 0042178 | biological_process | xenobiotic catabolic process |
| B | 0042262 | biological_process | DNA protection |
| B | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| B | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| B | 0106405 | molecular_function | isoprenoid diphosphate phosphatase activity |
| B | 0120557 | molecular_function | farnesyl diphosphatase activity |
| B | 1901292 | biological_process | nucleoside phosphate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 1101 |
| Chain | Residue |
| A | GLY47 |
| A | GLU63 |
| A | GLU67 |
| A | HOH1210 |
| A | HOH1211 |
| A | HOH1228 |
| A | HOH1263 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 71V A 1102 |
| Chain | Residue |
| A | PRO46 |
| A | GLY47 |
| A | GLY48 |
| A | HIS49 |
| A | TYR90 |
| A | PHE135 |
| A | GLY137 |
| A | LEU138 |
| A | HOH1211 |
| A | HOH1218 |
| A | HOH1227 |
| A | ARG34 |
| A | LEU45 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue MG B 1101 |
| Chain | Residue |
| B | GLU63 |
| B | GLU67 |
| B | MG1102 |
| B | MG1103 |
| B | MG1104 |
| B | HOH1209 |
| B | HOH1215 |
| B | HOH1230 |
| B | HOH1267 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 1102 |
| Chain | Residue |
| B | GLY47 |
| B | GLU67 |
| B | MG1101 |
| B | MG1103 |
| B | HOH1215 |
| B | HOH1227 |
| B | HOH1254 |
| B | HOH1257 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 1103 |
| Chain | Residue |
| B | GLY48 |
| B | MG1101 |
| B | MG1102 |
| B | MG1104 |
| B | HOH1215 |
| B | HOH1243 |
| B | HOH1264 |
| B | HOH1283 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 1104 |
| Chain | Residue |
| A | HOH1271 |
| B | GLU63 |
| B | MG1101 |
| B | MG1103 |
| B | HOH1214 |
| B | HOH1220 |
| B | HOH1243 |
| B | HOH1267 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 272 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 176 |
| Details | Region: {"description":"Interaction with PCNA","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26238318","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BON","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38944687","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7R0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26238318","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38944687","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7R0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
