5LMB

HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR

Summary for 5LMB

• Entry DOI: 10.2210/pdb5lmb/pdb
• Related: 5LMA
• Descriptor: Tyrosine-protein kinase SYK, 7-[6-(dimethylamino)pyridin-3-yl]-~{N}-[[(3~{S})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine, GLYCEROL, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 65695.56

Authors

Somers, D.O.,Neu, M. (deposition date: 2016-07-29, release date: 2016-09-14, Last modification date: 2019-04-03)

• Primary citation: Garton, N.S.,Barker, M.D.,Davis, R.P.,Douault, C.,Hooper-Greenhill, E.,Jones, E.,Lewis, H.D.,Liddle, J.,Lugo, D.,McCleary, S.,Preston, A.G.,Ramirez-Molina, C.,Neu, M.,Shipley, T.J.,Somers, D.O.,Watson, R.J.,Wilson, D.M.; Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.; Bioorg.Med.Chem.Lett., 26:4606-4612, 2016; PubMed: 27578246; DOI: 10.1016/j.bmcl.2016.08.070

Experimental method

X-RAY DIFFRACTION (1.95 Å)