5LMB
HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase SYK | polymer | 277 | 32162.0 | 2 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
2 | A, B | 7-[6-(dimethylamino)pyridin-3-yl]-~{N}-[[(3~{S})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine | non-polymer | 363.5 | 2 | Chemie (6ZF) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
4 | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B: 360 - 635 (UniProt: P43405)
PDB | External Database | Details |
---|---|---|
Gly 359 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64324.0 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1371.6 | |
All* | Total formula weight | 65695.6 |