5LLP

Crystal structure of human carbonic anhydrase isozyme XII with 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

Summary for 5LLP

Entry DOI	10.2210/pdb5llp/pdb
Related	5LLC 5LLE 5LLG 5LLH 5LLN 5LLO
Descriptor	Carbonic anhydrase 12, ZINC ION, 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, ... (4 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: O43570
Total number of polymer chains	4
Total formula weight	121788.82
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2016-07-28, release date: 2017-08-16, Last modification date: 2024-01-10)
Primary citation	Smirnov, A.,Zubriene, A.,Manakova, E.,Grazulis, S.,Matulis, D. Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6:e4412-e4412, 2018 Cited by PubMed: 29503769 DOI: 10.7717/peerj.4412 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation