5LHQ

The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7

5LHQ の概要

• エントリーDOI: 10.2210/pdb5lhq/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000288
• 分子名称: Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ... (6 entities in total)
• 機能のキーワード: trypsin-like serine proteases, nanobody, inhibitor, hydrolase-antibody complex, hydrolase/antibody
• 由来する生物種: Mus musculus (House Mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45434.78

構造登録者

Kromann-Hansen, T.,Lange, E.L.,Sorensen, H.P.,Ghassabeh, G.H.,Huang, M.,Jensen, J.K.,Muyldermans, S.,Declerck, P.J.,Andreasen, P.A. (登録日: 2016-07-12, 公開日: 2017-06-28, 最終更新日: 2024-01-10)

• 主引用文献: Kromann-Hansen, T.,Louise Lange, E.,Peter Srensen, H.,Hassanzadeh-Ghassabeh, G.,Huang, M.,Jensen, J.K.,Muyldermans, S.,Declerck, P.J.,Komives, E.A.,Andreasen, P.A.; Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.; Sci Rep, 7:3385-3385, 2017; PubMed: 28611361; DOI: 10.1038/s41598-017-03457-7

実験手法

X-RAY DIFFRACTION (2.6 Å)