5LBS

structural basis of Zika and Dengue virus potent antibody cross-neutralization

5LBS の概要

• エントリーDOI: 10.2210/pdb5lbs/pdb
• 関連するPDBエントリー: 4UTA 4UTB
• 分子名称: envelope protein E, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C8, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: immune system-viral protein complex, zika virus, broadly neutralizing antibody, immune system-viral protein
• 由来する生物種: Zika virus (ZIKV); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 158934.27

構造登録者

Vaney, M.C.,Rouvinski, A.,Barba-Spaeth, G.,Rey, F.A. (登録日: 2016-06-17, 公開日: 2016-07-06, 最終更新日: 2024-10-16)

主引用文献

Barba-Spaeth, G.,Dejnirattisai, W.,Rouvinski, A.,Vaney, M.C.,Medits, I.,Sharma, A.,Simon-Loriere, E.,Sakuntabhai, A.,Cao-Lormeau, V.M.,Haouz, A.,England, P.,Stiasny, K.,Mongkolsapaya, J.,Heinz, F.X.,Screaton, G.R.,Rey, F.A.
Structural basis of potent Zika-dengue virus antibody cross-neutralization.
Nature, 536:48-53, 2016

PubMed Abstract: Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue virus infections.

PubMed: 27338953
DOI: 10.1038/nature18938

実験手法

X-RAY DIFFRACTION (2.41 Å)