5LBS

structural basis of Zika and Dengue virus potent antibody cross-neutralization

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	envelope protein E	polymer	447	48492.5	2	UniProt (A0A120IIH9) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (A0A024B7W1) In PDB	Zika virus (ZIKV)
2	H, I	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C8	polymer	141	14617.8	2		Homo sapiens (HUMAN)
3	L, M	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C8	polymer	147	15871.4	2		Homo sapiens (HUMAN)
4	A, H, I, L, M	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
5	A, B, I	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
6		water	water		18.0	180	Chemie (HOH)

Sequence modifications

A, B: 1 - 408 (UniProt: A0A120IIH9)

PDB	External Database	Details
Gly 409	-	expression tag
Pro 410	-	expression tag
Phe 411	-	expression tag
Glu 412	-	expression tag
Asp 413	-	expression tag
Asp 414	-	expression tag
Asp 415	-	expression tag
Asp 416	-	expression tag
Lys 417	-	expression tag
Ala 418	-	expression tag
Gly 419	-	expression tag
Trp 420	-	expression tag
Ser 421	-	expression tag
His 422	-	expression tag
Pro 423	-	expression tag
Gln 424	-	expression tag
Phe 425	-	expression tag
Glu 426	-	expression tag
Lys 427	-	expression tag
Gly 428	-	expression tag
Gly 429	-	expression tag
Gly 430	-	expression tag
Ser 431	-	expression tag
Gly 432	-	expression tag
Gly 433	-	expression tag
Gly 434	-	expression tag
Ser 435	-	expression tag
Gly 436	-	expression tag
Gly 437	-	expression tag
Gly 438	-	expression tag
Ser 439	-	expression tag
Trp 440	-	expression tag
Ser 441	-	expression tag
His 442	-	expression tag
Pro 443	-	expression tag
Gln 444	-	expression tag
Phe 445	-	expression tag
Glu 446	-	expression tag
Lys 447	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	157963.3
Non-Polymers*	Number of molecules	14
	Total formula weight	970.9
All*	Total formula weight	158934.3

*Water molecules are not included.