5L7F

Crystal structure of MMP12 mutant K421A in complex with RXP470.1 conjugated with fluorophore Cy5,5 in space group P21.

Summary for 5L7F

• Entry DOI: 10.2210/pdb5l7f/pdb
• Related: 4GQL 5CZM 5L79
• Related PRD ID: PRD_000830
• Descriptor: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (10 entities in total)
• Functional Keywords: probes for optical imaging, mmp-12, metalloprotease, inflammation, aneurysm, fluorophore, cy5, 5, cyanine, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 39874.23

Authors

Tepshi, L.,Bordenave, T.,Rouanet-Mehouas, C.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2016-06-03, release date: 2016-09-14, Last modification date: 2024-01-10)

• Primary citation: Bordenave, T.,Helle, M.,Beau, F.,Georgiadis, D.,Tepshi, L.,Bernes, M.,Ye, Y.,Levenez, L.,Poquet, E.,Nozach, H.,Razavian, M.,Toczek, J.,Stura, E.A.,Dive, V.,Sadeghi, M.M.,Devel, L.; Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.; Bioconjug.Chem., 27:2407-2417, 2016; PubMed: 27564088; DOI: 10.1021/acs.bioconjchem.6b00377

Experimental method

X-RAY DIFFRACTION (1.8 Å)