5CZM
Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470
Summary for 5CZM
| Entry DOI | 10.2210/pdb5czm/pdb |
| Related PRD ID | PRD_000830 |
| Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | matrix, metallo elastase, mmp12, human, rxp470, macrophage, hydrolase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
| Total number of polymer chains | 1 |
| Total formula weight | 18626.62 |
| Authors | Rouanet-Mehouas, C.,Roselia, L.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2015-07-31, release date: 2016-08-10, Last modification date: 2024-01-10) |
| Primary citation | Rouanet-Mehouas, C.,Czarny, B.,Beau, F.,Cassar-Lajeunesse, E.,Stura, E.A.,Dive, V.,Devel, L. Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity. J. Med. Chem., 60:403-414, 2017 Cited by PubMed: 27996256DOI: 10.1021/acs.jmedchem.6b01420 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.303 Å) |
Structure validation
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