5L4H
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)
Summary for 5L4H
| Entry DOI | 10.2210/pdb5l4h/pdb |
| Descriptor | Proton-gated ion channel, CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, ... (5 entities in total) |
| Functional Keywords | membrane protein, transport protein |
| Biological source | Gloeobacter violaceus (strain PCC 7421) |
| Cellular location | Cell inner membrane ; Multi- pass membrane protein : Q7NDN8 |
| Total number of polymer chains | 5 |
| Total formula weight | 182078.99 |
| Authors | Fourati, Z.,Ruza, R.R.,Delarue, M. (deposition date: 2016-05-25, release date: 2016-12-21, Last modification date: 2017-02-15) |
| Primary citation | Fourati, Z.,Ruza, R.R.,Laverty, D.,Drege, E.,Delarue-Cochin, S.,Joseph, D.,Koehl, P.,Smart, T.,Delarue, M. Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State. J. Biol. Chem., 292:1550-1558, 2017 Cited by PubMed: 27986812DOI: 10.1074/jbc.M116.766964 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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