5L4E
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental
Summary for 5L4E
Entry DOI | 10.2210/pdb5l4e/pdb |
Descriptor | Proton-gated ion channel, DODECANE, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | membrane protein, barbiturates, transport protein |
Biological source | Gloeobacter |
Cellular location | Cell inner membrane ; Multi- pass membrane protein : Q7NDN8 |
Total number of polymer chains | 5 |
Total formula weight | 181717.96 |
Authors | Fourati, Z.,Ruza, R.R.,Delarue, M. (deposition date: 2016-05-25, release date: 2016-12-21, Last modification date: 2017-09-06) |
Primary citation | Fourati, Z.,Ruza, R.R.,Laverty, D.,Drege, E.,Delarue-Cochin, S.,Joseph, D.,Koehl, P.,Smart, T.,Delarue, M. Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State. J. Biol. Chem., 292:1550-1558, 2017 Cited by PubMed: 27986812DOI: 10.1074/jbc.M116.766964 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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