5L4E
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Proton-gated ion channel | polymer | 317 | 36225.6 | 5 | UniProt (Q7NDN8) Pfam (PF02931) | Gloeobacter | GLIC,Ligand-gated ion channel,LGIC |
| 2 | F (A) | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
| 3 | G, H, I, J, L (A, B, C, D, E) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 4 | K (D) | 5-ethyl-5-[(2R)-pentan-2-yl]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | non-polymer | 242.3 | 1 | Chemie (EDP) | |||
| 5 | M, N, O, P, Q (A, B, C, D, E) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 317 (UniProt: Q7NDN8)
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | Cys 69 | conflict |
| Cys 33 | Lys 75 | conflict |
| Cys 246 | Leu 288 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 181128.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 589.9 | |
| All* | Total formula weight | 181718.0 |
