5L42

Leishmania major Pteridine reductase 1 (PTR1) in complex with compound 3

Summary for 5L42

• Entry DOI: 10.2210/pdb5l42/pdb
• Descriptor: Pteridine reductase 1, (2~{R})-2-[3,4-bis(oxidanyl)phenyl]-6-oxidanyl-2,3-dihydrochromen-4-one, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (8 entities in total)
• Functional Keywords: leishmania major, pteridine reductase 1, ptr1, oxidoreductase
• Biological source: Leishmania major
• Total number of polymer chains: 4
• Total formula weight: 127146.27

Authors

Dello Iacono, L.,Di Pisa, F.,Pozzi, C.,Landi, G.,Mangani, S. (deposition date: 2016-05-24, release date: 2017-05-03, Last modification date: 2024-01-10)

• Primary citation: Di Pisa, F.,Landi, G.,Dello Iacono, L.,Pozzi, C.,Borsari, C.,Ferrari, S.,Santucci, M.,Santarem, N.,Cordeiro-da-Silva, A.,Moraes, C.B.,Alcantara, L.M.,Fontana, V.,Freitas-Junior, L.H.,Gul, S.,Kuzikov, M.,Behrens, B.,Pohner, I.,Wade, R.C.,Costi, M.P.,Mangani, S.; Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.; Molecules, 22:-, 2017; PubMed: 28282886; DOI: 10.3390/molecules22030426

Experimental method

X-RAY DIFFRACTION (2.1 Å)