5L42
Leishmania major Pteridine reductase 1 (PTR1) in complex with compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pteridine reductase 1 | polymer | 288 | 30456.6 | 4 | UniProt (Q01782) Pfam (PF13561) | Leishmania major | H region methotrexate resistance protein |
| 2 | E, O, U, Y (A, B, C, D) | (2~{R})-2-[3,4-bis(oxidanyl)phenyl]-6-oxidanyl-2,3-dihydrochromen-4-one | non-polymer | 272.3 | 4 | Chemie (6J6) | |||
| 3 | F, P, V, Z (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 4 | G, H, Q, R, S... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 5 | I, J, K, T (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 6 | L (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | AA, BA, M, N, X (D, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 8 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 840 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 288 (UniProt: Q01782)
| PDB | External Database | Details |
|---|---|---|
| Val 162 | Phe 162 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121826.3 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5319.9 | |
| All* | Total formula weight | 127146.3 |
