5L1E

AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor CP465022

5L1E の概要

• エントリーDOI: 10.2210/pdb5l1e/pdb
• 関連するPDBエントリー: 5L1B 5L1F 5L1G 5L1H
• 分子名称: Glutamate receptor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino)methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one (3 entities in total)
• 機能のキーワード: transporter, membrane protein, transport protein, transport protein-inhibitor complex, transport protein/inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 361967.62

構造登録者

Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Sobolevsky, A.I. (登録日: 2016-07-29, 公開日: 2016-10-19, 最終更新日: 2023-10-04)

• 主引用文献: Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Narangoda, C.,Kurnikova, M.,Sobolevsky, A.I.; Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.; Neuron, 91:1305-1315, 2016; PubMed: 27618672; DOI: 10.1016/j.neuron.2016.08.012

実験手法

X-RAY DIFFRACTION (4.37 Å)