5L0G

Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2

Summary for 5L0G

Entry DOI	10.2210/pdb5l0g/pdb
Descriptor	Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (3 entities in total)
Functional Keywords	5-helix bundle, cytoskelatal protein, phospholipids, cell adhesion, structural protein
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : P18206
Total number of polymer chains	4
Total formula weight	80144.12
Authors	Chinthalapudi, K.,Izard, T. (deposition date: 2016-07-27, release date: 2016-08-31, Last modification date: 2023-10-04)
Primary citation	Chinthalapudi, K.,Rangarajan, E.S.,Brown, D.T.,Izard, T. Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113:9539-9544, 2016 Cited by PubMed: 27503891 DOI: 10.1073/pnas.1600702113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation