5KSC
E166A/R274N/R276N Toho-1 Beta-lactamase aztreonam acyl-enzyme intermediate
Summary for 5KSC
Entry DOI | 10.2210/pdb5ksc/pdb |
Descriptor | Beta-lactamase Toho-1, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid (3 entities in total) |
Functional Keywords | beta-lactamase, aztreonam, acyl-intermediate, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 28484.13 |
Authors | Vandavasi, V.G.,Langan, P.S.,Weiss, K.,Parks, J.M.,Cooper, J.B.,Ginell, S.L.,Coates, L. (deposition date: 2016-07-08, release date: 2016-11-09, Last modification date: 2024-10-09) |
Primary citation | Vandavasi, V.G.,Langan, P.S.,Weiss, K.L.,Parks, J.M.,Cooper, J.B.,Ginell, S.L.,Coates, L. Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A beta-Lactamase with a Monobactam Substrate. Antimicrob. Agents Chemother., 61:-, 2017 Cited by PubMed: 27795378DOI: 10.1128/AAC.01636-16 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.1 Å) |
Structure validation
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