5KSC
E166A/R274N/R276N Toho-1 Beta-lactamase aztreonam acyl-enzyme intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-lactamase Toho-1 | polymer | 261 | 28046.7 | 1 | UniProt (Q47066) Pfam (PF00144) Pfam (PF00905) Pfam (PF13354) | Escherichia coli | |
| 2 | B (A) | 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid | non-polymer | 437.4 | 1 | Chemie (AZR) | |||
| 3 | C (A) | water | water | 18.0 | 29 | Chemie (DOD) |
Sequence modifications
A: 27 - 287 (UniProt: Q47066)
| PDB | External Database | Details |
|---|---|---|
| Ala 165 | Glu 169 | engineered mutation |
| Asn 271 | Arg 275 | engineered mutation |
| Asn 273 | Arg 277 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28046.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 437.4 | |
| All* | Total formula weight | 28484.1 |
