5KR7
KDM4C bound to pyrazolo-pyrimidine scaffold
Summary for 5KR7
Entry DOI | 10.2210/pdb5kr7/pdb |
Descriptor | Lysine-specific demethylase 4C, FE (II) ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | inhibitor, histone, lysine demethylase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q9H3R0 |
Total number of polymer chains | 2 |
Total formula weight | 85420.44 |
Authors | Bellon, S.F.,Poy, F.,Setser, J.W. (deposition date: 2016-07-07, release date: 2016-08-17, Last modification date: 2023-10-04) |
Primary citation | Gehling, V.S.,Bellon, S.F.,Harmange, J.C.,LeBlanc, Y.,Poy, F.,Odate, S.,Buker, S.,Lan, F.,Arora, S.,Williamson, K.E.,Sandy, P.,Cummings, R.T.,Bailey, C.M.,Bergeron, L.,Mao, W.,Gustafson, A.,Liu, Y.,VanderPorten, E.,Audia, J.E.,Trojer, P.,Albrecht, B.K. Identification of potent, selective KDM5 inhibitors. Bioorg.Med.Chem.Lett., 26:4350-4354, 2016 Cited by PubMed: 27476424DOI: 10.1016/j.bmcl.2016.07.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report