5KR7

KDM4C bound to pyrazolo-pyrimidine scaffold

Summary for 5KR7

Entry DOI	10.2210/pdb5kr7/pdb
Descriptor	Lysine-specific demethylase 4C, FE (II) ION, ZINC ION, ... (6 entities in total)
Functional Keywords	inhibitor, histone, lysine demethylase, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q9H3R0
Total number of polymer chains	2
Total formula weight	85420.44
Authors	Bellon, S.F.,Poy, F.,Setser, J.W. (deposition date: 2016-07-07, release date: 2016-08-17, Last modification date: 2023-10-04)
Primary citation	Gehling, V.S.,Bellon, S.F.,Harmange, J.C.,LeBlanc, Y.,Poy, F.,Odate, S.,Buker, S.,Lan, F.,Arora, S.,Williamson, K.E.,Sandy, P.,Cummings, R.T.,Bailey, C.M.,Bergeron, L.,Mao, W.,Gustafson, A.,Liu, Y.,VanderPorten, E.,Audia, J.E.,Trojer, P.,Albrecht, B.K. Identification of potent, selective KDM5 inhibitors. Bioorg.Med.Chem.Lett., 26:4350-4354, 2016 Cited by PubMed: 27476424 DOI: 10.1016/j.bmcl.2016.07.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation