5KQZ
Protease E35D-CaP2
Summary for 5KQZ
Entry DOI | 10.2210/pdb5kqz/pdb |
Related | 5KQX 5KQY 5KR0 5KR1 5KR2 |
Related PRD ID | PRD_000349 |
Descriptor | Protease, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total) |
Functional Keywords | hiv-1 protease, e35d, salt-bridge interaction, natural polymorphism, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22284.38 |
Authors | Liu, Z.,Poole, K.M.,Mahon, B.P.,McKenna, R.,Fanucci, G.E. (deposition date: 2016-07-06, release date: 2016-09-21, Last modification date: 2024-03-06) |
Primary citation | Liu, Z.,Huang, X.,Hu, L.,Pham, L.,Poole, K.M.,Tang, Y.,Mahon, B.P.,Tang, W.,Li, K.,Goldfarb, N.E.,Dunn, B.M.,McKenna, R.,Fanucci, G.E. Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291:22741-22756, 2016 Cited by PubMed: 27576689DOI: 10.1074/jbc.M116.747568 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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