5KNT
Crystal structure of E. coli hypoxanthine phosphoribosyltransferase in complexed with 2-((2,3-Dihydroxypropyl)(2-(hypoxanthin-9-yl)ethyl)amino)ethylphosphonic acid
Summary for 5KNT
Entry DOI | 10.2210/pdb5knt/pdb |
Related | 5KNP 5KNQ 5KNR 5KNS 5KNU 5KNV 5KNX 5KNY |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, 2-[[(2~{S})-2,3-bis(oxidanyl)propyl]-[2-(6-oxidanylidene-1~{H}-purin-9-yl)ethyl]amino]ethylphosphonic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 42272.91 |
Authors | Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2023-09-27) |
Primary citation | Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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