5KNS

E coli hypoxanthine guanine phosphoribosyltransferase in complexed with 9-[(N-phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]hypoxanthine

Summary for 5KNS

Entry DOI	10.2210/pdb5kns/pdb
Related	5KNP 5KNQ 5KNR 5KNT 5KNU 5KNV 5KNX 5KNY
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	42687.50
Authors	Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2024-03-06)
Primary citation	Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.792 Å)

Structure validation