5KNS

E coli hypoxanthine guanine phosphoribosyltransferase in complexed with 9-[(N-phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]hypoxanthine

5KNS の概要

• エントリーDOI: 10.2210/pdb5kns/pdb
• 関連するPDBエントリー: 5KNP 5KNQ 5KNR 5KNT 5KNU 5KNV 5KNX 5KNY
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42687.50

構造登録者

Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z. (登録日: 2016-06-28, 公開日: 2017-07-19, 最終更新日: 2024-03-06)

• 主引用文献: Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W.; Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase; Chemistryselect, 1:6267-6276, 2016; DOI: 10.1002/slct.201601679

実験手法

X-RAY DIFFRACTION (2.792 Å)