5KML
TrkA JM-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea
Summary for 5KML
Entry DOI | 10.2210/pdb5kml/pdb |
Related | 5KMI 5KMJ 5KMK 5KMM 5KMN 5KMO |
Descriptor | High affinity nerve growth factor receptor, 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea (3 entities in total) |
Functional Keywords | kinase, juxtamembrane, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P04629 |
Total number of polymer chains | 1 |
Total formula weight | 37668.13 |
Authors | Su, H.P. (deposition date: 2016-06-27, release date: 2016-12-28, Last modification date: 2017-02-01) |
Primary citation | Su, H.P.,Rickert, K.,Burlein, C.,Narayan, K.,Bukhtiyarova, M.,Hurzy, D.M.,Stump, C.A.,Zhang, X.,Reid, J.,Krasowska-Zoladek, A.,Tummala, S.,Shipman, J.M.,Kornienko, M.,Lemaire, P.A.,Krosky, D.,Heller, A.,Achab, A.,Chamberlin, C.,Saradjian, P.,Sauvagnat, B.,Yang, X.,Ziebell, M.R.,Nickbarg, E.,Sanders, J.M.,Bilodeau, M.T.,Carroll, S.S.,Lumb, K.J.,Soisson, S.M.,Henze, D.A.,Cooke, A.J. Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A., 114:E297-E306, 2017 Cited by PubMed: 28039433DOI: 10.1073/pnas.1611577114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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