5KMJ
TrkA JM-kinase with {N}-(2-pyridylmethyl)-2-[2-(2-thienyl)indol-1-yl]acetamide
Summary for 5KMJ
Entry DOI | 10.2210/pdb5kmj/pdb |
Related | 5KMI 5KMK 5KML 5KMM 5KMN 5KMO |
Descriptor | High affinity nerve growth factor receptor, ~{N}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide (3 entities in total) |
Functional Keywords | kinase, juxtamembrane, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P04629 |
Total number of polymer chains | 1 |
Total formula weight | 37614.18 |
Authors | Su, H.P. (deposition date: 2016-06-27, release date: 2016-12-28, Last modification date: 2023-09-27) |
Primary citation | Su, H.P.,Rickert, K.,Burlein, C.,Narayan, K.,Bukhtiyarova, M.,Hurzy, D.M.,Stump, C.A.,Zhang, X.,Reid, J.,Krasowska-Zoladek, A.,Tummala, S.,Shipman, J.M.,Kornienko, M.,Lemaire, P.A.,Krosky, D.,Heller, A.,Achab, A.,Chamberlin, C.,Saradjian, P.,Sauvagnat, B.,Yang, X.,Ziebell, M.R.,Nickbarg, E.,Sanders, J.M.,Bilodeau, M.T.,Carroll, S.S.,Lumb, K.J.,Soisson, S.M.,Henze, D.A.,Cooke, A.J. Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A., 114:E297-E306, 2017 Cited by PubMed: 28039433DOI: 10.1073/pnas.1611577114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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