5KKR
KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79
Summary for 5KKR
Entry DOI | 10.2210/pdb5kkr/pdb |
Descriptor | Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine (3 entities in total) |
Functional Keywords | kinase suppressor of ras small molecule complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 80798.08 |
Authors | Dhawan, N.S.,Scopton, A.P.,Dar, A.C. (deposition date: 2016-06-22, release date: 2016-08-31, Last modification date: 2023-09-27) |
Primary citation | Dhawan, N.S.,Scopton, A.P.,Dar, A.C. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature, 537:112-116, 2016 Cited by PubMed: 27556948DOI: 10.1038/nature19327 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.509 Å) |
Structure validation
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