5KKL

Structure of ctPRC2 in complex with H3K27me3 and H3K27M

5KKL の概要

• エントリーDOI: 10.2210/pdb5kkl/pdb
• 分子名称: putative polycomb protein Eed, Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein, ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA, ... (5 entities in total)
• 機能のキーワード: complex, methyltransferase, histone h3, transferase
• 由来する生物種: Chaetomium thermophilum; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 174980.00

構造登録者

Jiao, L.,Liu, X. (登録日: 2016-06-21, 公開日: 2017-04-19, 最終更新日: 2023-09-27)

主引用文献

Jiao, L.,Liu, X.
Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354:1543-1543, 2016

PubMed Abstract: Zhang et al suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.

PubMed: 28008038
DOI: 10.1126/science.aaj2335

実験手法

X-RAY DIFFRACTION (2.94 Å)